5-fluoroorotic acid

Term ID

CHEBI:74498

Synonyms

• 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylic acid
• 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid
• 5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
• 5-fluoro-6-carboxyuracil
• 5-fluorouracil-4-carboxylic acid
• ENT-26398
• FO
• FOA
• NSC 31712
• NSC-31712
• Ro 2-9945

Definition

A pyrimidinemonocarboxylic that is orotic acid which is substituted by fluorine at position 5. It is used in yeast molecular genetics to detect expression of the URA3 gene, which encodes orotine-5'-monophosphate dicarboxylase. A yeast with and active URA3 gene converts 5-fluoroorotic acid to fluorodeoxyuridine, which is toxic to cells.

References

• CAS:703-95-7
• PMID:2675756
• PMID:3323810
• PMID:3586772
• Patent:GB806584
• Patent:US2948725
• Reaxys:181933

Ontology

ChEBI  ( EBI )

Resources

CTD