nafarelin

Term ID

CHEBI:7445

Synonyms

• (2S)-N-(2-amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-(2-methylpropyl)-8-(naphthalen-2-ylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-
• 5-oxo-L-prolyl L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-3-(2-naphthyl)-D-alanyl-L-leucyl-L-arginyl-L-prolylglycinamide
• [6-D-(2-naphthyl)alanine]-GnRH
• L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-3-(2-naphthyl)-D-alanyl-L-leucyl-L-arginyl-L-prolyl-glycinamide
• nafarelin
• nafarelina
• nafareline
• nafarelinum

Definition

An oligopeptide comprising of 5-oxo-L-proline, L-histidine, L-tryptophan, L-serine, L-tyrosine, 3-(2-naphthyl)-D-alanine, L-leucine, L-arginine and L-prolylglycinamide residues joined sequence by peptide linkages. It is a gonadotropin releasing hormone agonist that is used to treat central precocious puberty in children and endometriosis in women.

References

• cas:76932-56-4
• chemspider:10605761
• drugbank:DB00666
• drugcentral:1868
• hmdb:HMDB0014804
• kegg.compound:C07613
• kegg.drug:D08241
• pubmed:10900577
• pubmed:10900582
• pubmed:10983507
• pubmed:11212082
• pubmed:11228063
• pubmed:11788185
• pubmed:1386133
• pubmed:1531580
• pubmed:16038370
• pubmed:2143265
• pubmed:28430010
• pubmed:7716957
• pubmed:8569395
• pubmed:8967550
• pubmed:9209899
• pubmed:9252932
• pubmed:9663373
• wikipedia.en:Nafarelin

Ontology

ChEBI  ( EBI )

Resources

CTD