masoprocol

Term ID

CHEBI:73468

Synonyms

• 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
• Actinex
• CHX 100
• CHX-100
• erythro-nordihydroguaiaretic acid
• masoprocol
• masoprocolum
• meso-1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane
• meso-2,3-bis(3,4-dihydroxyphenylmethyl)butane
• meso-4,4'-(2,3-dimethyl-1,4-butanediyl)bis(pyrocatechol)
• meso-4,4'-(2,3-dimethyltetramethylene)dipyrocatechol
• meso-4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
• meso-beta,gamma-dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butan
• meso-NDGA
• meso-nordihydroguaiaretic acid

Definition

The meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase.

References

• cas:27686-84-6
• cas:500-38-9
• drugbank:DB00179
• drugcentral:1637
• hmdb:HMDB0014325
• kegg.compound:C10719
• kegg.drug:D04862
• knapsack:C00000693
• pubmed:10027587
• pubmed:10206430
• pubmed:10411373
• pubmed:10950827
• pubmed:11016888
• pubmed:15814253
• pubmed:18672930
• pubmed:1869646
• pubmed:8040425
• pubmed:8412980
• pubmed:9169274
• pubmed:9617755
• reaxys:2056826
• reaxys:9874298
• wikipedia.en:Masoprocol

Ontology

ChEBI  ( EBI )