(-)-noscapine

Term ID

CHEBI:73237

Synonyms

• (-)-alpha-narcotine
• (-)-narcotine
• (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one
• alpha-Narcotine
• noscapina
• noscapine
• noscapinum

Definition

A benzylisoquinoline alkaloid that is 1,2,3,4-tetrahydroisoquinoline which is substituted by a 4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl group at position 1, a methylenedioxy group at positions 6-7 and a methoxy group at position 8. Obtained from plants of the Papaveraceae family, it lacks significant painkilling properties and is primarily used for its antitussive (cough-suppressing) effects.

References

• cas:128-62-1
• drugcentral:1973
• hmdb:HMDB0033439
• kegg.compound:C09592
• kegg.drug:D01036
• knapsack:C00001891
• lincs.smallmolecule:LSM-3997
• metacyc.compound:CPD-14834
• pubmed:22079300
• pubmed:22546556
• pubmed:22653730
• pubmed:22671862
• pubmed:22733149
• pubmed:22848370
• pubmed:22935070
• pubmed:23117045
• reaxys:99933
• wikipedia.en:Noscapine

Ontology

ChEBI  ( EBI )

Resources

CTD