Search Ontology:
ChEBI
arglabin
- Term ID
- CHEBI:73228
- Synonyms
-
- (+)-arglabin
- (3aR,4aS,6aS,9aS,9bR)-1,4a-dimethyl-7-methylene-5,6,6a,7,9a,9b-hexahydro-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one
- 1beta,10beta-epoxyguaia-3,11(13)-dien-12,6alpha-olide
- Definition
- An organic heterotetracyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-dimethyl-1,3a,4,5,6,7-hexahydroazulen-5-yl group in which the double bond in the 7-membered ring has been epoxidised and in which the hydroxy group and the carboxy group have undergone formal condensation to give the corresponding gamma-lactone. It is found in Artemisia glabella. Arglabin-DMA HCl, the hydrochloride salt of the adduct resulting from the conjugate addition of dimethylamine to the ene-lactone moiety, has been successfully used in Khazakhstan for the treatment of breast, colon, ovarian and lung cancers.
- References
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- CAS:84692-91-1
- PMID:15079907
- PMID:17634992
- PMID:21997763
- PMID:22849854
- PMID:8374514
- Patent:US6770673
- Reaxys:3549528
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
-
- has_role
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- inverse has_functional_parent
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Show first 5 Terms
Phenotype
Phenotype resulting from arglabin
Phenotype where environments contain arglabin
Phenotype modified by environments containing arglabin
Human Disease Model