L-BMAA

Term ID

CHEBI:73169

Synonyms

3-(methylamino)-L-alanine
beta-N-methylamino-L-alanine
BMAA
L-alpha-amino-beta-(methylamino)propanoic acid
L-alpha-amino-beta-(methylamino)propionic acid

Definition

A non-proteinogenic L-α-amino acid that is L-alanine in which one of the methyl hydrogens is replaced by a methylamino group. A non-proteinogenic amino acid produced by cyanobacteria, it is a neurotoxin that has been postulated as a possible cause of neurodegenerative disorders of aging such as Alzheimer's disease, amyotrophic lateral sclerosis, and the amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS-PDC) syndrome of Guam.

References

cas:15920-93-1
kegg.compound:C08291
knapsack:C00001380
pubmed:19114054
pubmed:19272457
pubmed:19309437
pubmed:19929728
pubmed:20561540
pubmed:21057660
pubmed:21236519
pubmed:22069578
pubmed:22214351
pubmed:23047912
pubmed:23123117
pubmed:23146671
pubmed:23180086
pubmed:23246360
pubmed:23328118
pubmed:23508043
pubmed:2666171
reaxys:4781252
wikipedia.en:BMAA

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from L-BMAA

Phenotype where environments contain L-BMAA

Phenotype modified by environments containing L-BMAA

Phenotype affecting L-BMAA

Human Disease Model