pasireotide

Term ID

CHEBI:72312

Synonyms

cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L- phenylalanyl-)
cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-benzyl-L-tyrosyl-L-phenylalanyl-(4R)-4-{[(2-aminoethyl)carbamoyl]oxy}-L-prolyl]
pasireotida
pasireotide
pasireotidum
SOM 230
SOM-230
SOM230

Definition

A six-membered homodetic cyclic peptide composed from L-phenylglycyl, D-tryptophyl, L-lysyl, O-benzyl-L-tyrosyl, L-phenylalanyl and modified L-hydroxyproline residues joined in sequence. A somatostatin analogue with pharmacologic properties mimicking those of the natural hormone somatostatin; used (as its diaspartate salt) for treatment of Cushing's disease.

References

cas:396091-73-9
kegg.drug:D10147
pubmed:20643121
pubmed:20970474
pubmed:21264796
pubmed:21330405
pubmed:21493671
pubmed:21506098
pubmed:21525729
pubmed:21532334
pubmed:21673137
pubmed:21732759
pubmed:22170729
pubmed:22282526
pubmed:22383336
pubmed:22573933
pubmed:22634958
pubmed:22713526
pubmed:22736724
pubmed:22745760
pubmed:22807497
pubmed:22960304
pubmed:22965070
pubmed:23102680
pubmed:23137853
pubmed:23345100
reaxys:9469122
wikipedia.en:Pasireotide

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from pasireotide

Phenotype where environments contain pasireotide

Phenotype modified by environments containing pasireotide

Phenotype affecting pasireotide

Human Disease Model