bedaquiline

Term ID

CHEBI:72292

Synonyms

(1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenylbutan-2-ol
1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol
bedaquilina
bedaquiline
bedaquilinum
R 207910
R207910
TMC 207
TMC-207
TMC207

Definition

A quinoline-based antimycobacterial drug used (as its fumarate salt) for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of the mycobacteria.

References

cas:654653-93-7
cas:843663-66-1
drugbank:DB08903
drugcentral:4741
kegg.drug:D09872
patent:WO2005117875
patent:WO2006067048
pdb-ccd:BQ1
pubmed:18948422
pubmed:19954909
pubmed:20038615
pubmed:21659613
pubmed:21858172
pubmed:21877185
pubmed:22126739
pubmed:22155815
pubmed:22279595
pubmed:22332895
pubmed:22354303
pubmed:22391540
pubmed:22470112
pubmed:22615276
pubmed:22622957
pubmed:22762423
pubmed:22828481
pubmed:22926573
pubmed:22991970
pubmed:23089752
pubmed:23291974
pubmed:26601184
pubmed:33299175
pubmed:36588483
pubmed:37536359
pubmed:37619292
pubmed:37860115
pubmed:37874928
pubmed:37931639
pubmed:38011249
pubmed:38043563
pubmed:38115043
pubmed:38134888
pubmed:38156185
pubmed:38345388
pubmed:38407158
pubmed:38481348
pubmed:38664815
reaxys:10733008
wikipedia.en:Bedaquiline

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from bedaquiline

Phenotype where environments contain bedaquiline

Phenotype modified by environments containing bedaquiline

Phenotype affecting bedaquiline

Human Disease Model