cobicistat

Term ID

CHEBI:72291

Synonyms

• 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate
• cobicistat
• cobicistatum
• GS 9350
• GS-9350

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoic acid with the amino group of 1,3-thiazol-5-ylmethyl [(2R,5R)-5-amino-1,6-diphenylhexan-2-yl]carbamate. Acts as a pharmacoenhancer in treatment of HIV-1 by inhibiting P450 enzymes that metabolise other medications..

References

• cas:1004316-88-4
• drugcentral:4299
• patent:US2010256366
• patent:WO2008010921
• patent:WO2012151165
• pubmed:20043009
• pubmed:20683270
• pubmed:21348537
• pubmed:22732469
• pubmed:22766666
• pubmed:22833060
• pubmed:22850510
• pubmed:22886031
• pubmed:23136357
• pubmed:23243633
• reaxys:13088386
• wikipedia.en:Cobicistat

Ontology

ChEBI  ( EBI )