dactolisib

Term ID

CHEBI:71952

Synonyms

• 2-methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile
• BEZ 235
• BEZ-235
• BEZ235
• NVP BEZ235
• NVP-BEZ 235
• NVP-BEZ235
• NVPBEZ235

Definition

An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.

References

• CAS:915019-65-7
• LINCS:LSM-4255
• PMID:22020918
• PMID:22154651
• PMID:22218692
• PMID:22287733
• PMID:22299028
• PMID:22355272
• PMID:22401294
• PMID:22415236
• PMID:22452803
• PMID:22560334
• PMID:22662154
• PMID:22727754
• PMID:22858987
• PMID:22895065
• PMID:22920938
• PMID:22960230
• PMID:22989521
• PMID:23077520
• PMID:23215722
• PMID:23232026
• PMID:23300274
• PMID:23319394
• PMID:23319457
• PMID:23321494
• PMID:23343422
• Patent:WO2006122806
• Patent:WO2008064093
• Reaxys:12748665

Ontology

ChEBI  ( EBI )