Search Ontology:
ChEBI
dactolisib
- Term ID
- CHEBI:71952
- Synonyms
-
- 2-methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile
- BEZ 235
- BEZ-235
- BEZ235
- NVP BEZ235
- NVP-BEZ 235
- NVP-BEZ235
- NVPBEZ235
- Definition
- An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.
- References
-
- cas:915019-65-7
- lincs.smallmolecule:LSM-4255
- patent:WO2006122806
- patent:WO2008064093
- pubmed:22020918
- pubmed:22154651
- pubmed:22218692
- pubmed:22287733
- pubmed:22299028
- pubmed:22355272
- pubmed:22401294
- pubmed:22415236
- pubmed:22452803
- pubmed:22560334
- pubmed:22662154
- pubmed:22727754
- pubmed:22858987
- pubmed:22895065
- pubmed:22920938
- pubmed:22960230
- pubmed:22989521
- pubmed:23077520
- pubmed:23215722
- pubmed:23232026
- pubmed:23300274
- pubmed:23319394
- pubmed:23319457
- pubmed:23321494
- pubmed:23343422
- reaxys:12748665
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from dactolisib
Phenotype where environments contain dactolisib
Phenotype modified by environments containing dactolisib
Phenotype affecting dactolisib
Human Disease Model