tadalafil

Term ID

CHEBI:71940

Synonyms

• (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
• (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
• (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
• 6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1',2':1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE
• Adcirca
• Cialis
• tadalafil

Definition

A pyrazinopyridoindole that is 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione substituted at position 2 by a methyl group and at position 6 by a 1,3-benzodioxol-5-yl group (the 6R,12aR-diastereomer). A phosphodiesterase V inhibitor inhibitor, currently marketed in pill form for treating erectile dysfunction under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.

References

• CAS:171596-29-5
• DrugBank:DB00820
• Drug_Central:2553
• HMDB:HMDB0014958
• KEGG:D02008
• LINCS:LSM-4109
• PDBeChem:CIA
• PMID:21056623
• PMID:21680058
• PMID:22014651
• PMID:22328305
• PMID:22494518
• PMID:22776546
• PMID:22816778
• PMID:22971615
• PMID:22982422
• PMID:22996758
• PMID:23033484
• PMID:23072271
• PMID:23118430
• PMID:23140258
• PMID:23190275
• PMID:23216015
• PMID:23219525
• PMID:23234619
• PMID:23312193
• PMID:23346990
• PMID:23347176
• Patent:EP2107059
• Patent:EP2238979
• Patent:US2003229080
• Patent:US2004157847
• Patent:WO2005068464
• Patent:WO2007113243
• Patent:WO2009144734
• Patent:WO2010049500
• Patent:WO2012107549
• Reaxys:9589181
• Wikipedia:Tadalafil

Ontology

ChEBI  ( EBI )