procarbazine hydrochloride

Term ID

CHEBI:71428

Synonyms

1-(p-Isopropylcarbamoylbenzyl)-2-methylhydrazine hydrochloride
1-Methyl-2-(p-isopropylcarbamoylbenzyl)hydrazine hydrochloride
1-Methyl-2-p-(isopropylcarbamoyl)benzohydrazine hydrochloride
2-(p-(Isopropylcarbamoyl)benzyl)-1-methylhydrazine hydrochloride
N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride
N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride
N-Isopropyl-p-(2-methylhydrazinomethyl)benzamide hydrochloride
Procarbazine HCl
procarbazine monohydrochloride

Definition

A hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.

References

cas:366-70-1
drugbank:DB01168
kegg.compound:C07376
kegg.drug:D00478
patent:GB2480472
patent:WO2005072705
patent:WO2008100985
pubmed:1097949
pubmed:1209725
pubmed:16690522
pubmed:20412004
pubmed:21603918
pubmed:21863086
pubmed:2607014
pubmed:2747729
pubmed:3079944
pubmed:3185586
pubmed:323527
pubmed:3687991
pubmed:3838228
pubmed:4927302
pubmed:62854
pubmed:641741
pubmed:7022795
pubmed:713008
pubmed:7380952
pubmed:7384804
pubmed:7416483
pubmed:792579
pubmed:843152
reaxys:4024454

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from procarbazine hydrochloride

Phenotype where environments contain procarbazine hydrochloride

Phenotype modified by environments containing procarbazine hydrochloride

Phenotype affecting procarbazine hydrochloride

Human Disease Model