asenapine maleate

Term ID

CHEBI:71245

Synonyms

(+-)-asenapine maleate
(3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo(2,3:6,7)oxepino(4,5-c)pyrrole (2Z)-2-butenedioate
(3aRS,12bRS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-2-ium (2Z)-3-prop-2-enoate
(3aRS,12bRS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-but-2-enedioate
rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-2-ium (2Z)-3-prop-2-enoate
rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-but-2-enedioate
Saphris
trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate

Definition

A racemate consisting of equal amounts of (R,R)- and (S,S)-asenapine maleate. Used for the acute treatment of schizophrenia and acute treatment of manic or mixed episodes associated with bipolar I disorder with or without psychotic features.

References

cas:85650-56-2
kegg.drug:D02995
patent:EP1917267
patent:KR20080005253
patent:NZ562124
patent:WO2011159903
patent:ZA200708493
pmc:PMC3368685
pubmed:17440629
pubmed:17609744
pubmed:19088949
pubmed:19229381
pubmed:19876039
pubmed:20135021
pubmed:20216523
pubmed:20232719
pubmed:20448862
pubmed:20950326
pubmed:21274390
pubmed:21323396
pubmed:21446639
pubmed:21651314
pubmed:22778826
reaxys:3647286
wikipedia.en:Asenapine

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from asenapine maleate

Phenotype where environments contain asenapine maleate

Phenotype modified by environments containing asenapine maleate

Phenotype affecting asenapine maleate

Human Disease Model