ceftaroline fosamil

Term ID

CHEBI:70718

Synonyms

• (6R,7R)-7-({(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl}amino)-3-{[4-(1-methylpyridinium-4-yl)-1,3-thiazol-2-yl]sulfanyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 7-({(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl}amino)-3-{[4-(1-methylpyridinium-4-yl)-1,3-thiazol-2-yl]sulfanyl}-3,4-didehydrocepham-4-carboxylate
• ceftarolina fosamilo
• ceftaroline fosamil
• ceftarolinum fosamilum

Definition

A cephalosporin having [4-(1-methylpyridinium-4-yl)-1,3-thiazol-2-yl]sulfanyl and {(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl}amino side groups located at positions 3 and 7 respectively. The N-phospho prodrug of ceftaroline, a broad-spectrum antibiotic active against methicillin-resistant Staphylococcus aureus (MRSA). It is used for the treatment of adults with acute bacterial skin and skin structure infections.

References

• cas:229016-73-3
• drugcentral:4169
• patent:MX2012003411
• pubmed:21076711
• pubmed:21115453
• pubmed:21115454
• pubmed:21115455
• pubmed:21115456
• pubmed:21162631
• pubmed:21252841
• pubmed:21393213
• pubmed:21482565
• pubmed:21482566
• pubmed:21482568
• pubmed:21482570
• pubmed:21548186
• pubmed:21897727
• pubmed:22058102
• pubmed:22314524
• pubmed:22330908
• pubmed:22354289
• pubmed:22355258
• pubmed:22594846
• pubmed:22779432
• pubmed:22903949
• pubmed:22985880
• pubmed:29017833
• reaxys:9535806
• wikipedia.en:Ceftaroline_fosamil

Ontology

ChEBI  ( EBI )