eribulin mesylate

Term ID

CHEBI:70710

Synonyms

• 2-(3-amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one methanesulfonate
• E 7389
• E7389
• Eribulin mesilate
• Halaven

Definition

A methanesulfonate salt obtained by reaction of eribulin with one equivalent of methanesulfonic acid. A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage.

References

• cas:441045-17-6
• kegg.drug:D08914
• pubmed:21375468
• pubmed:21526355
• pubmed:21550727
• pubmed:21862415
• pubmed:21887501
• pubmed:21903605
• pubmed:21935916
• pubmed:21989327
• pubmed:22162924
• pubmed:22198425
• pubmed:22216781
• pubmed:22282463
• pubmed:22291464
• pubmed:22514495
• pubmed:22517020
• pubmed:22555773
• pubmed:22593439
• pubmed:22619477
• pubmed:22694309
• pubmed:22739019
• pubmed:22803519
• pubmed:22829199
• pubmed:22953094
• pubmed:23010853
• reaxys:11271529

Ontology

ChEBI  ( EBI )