Search Ontology:
ChEBI
eribulin mesylate
- Term ID
- CHEBI:70710
- Synonyms
-
- 2-(3-amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one methanesulfonate
- E 7389
- E7389
- Eribulin mesilate
- Halaven
- Definition
- A methanesulfonate salt obtained by reaction of eribulin with one equivalent of methanesulfonic acid. A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage.
- References
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- CAS:441045-17-6
- KEGG:D08914
- PMID:21375468
- PMID:21526355
- PMID:21550727
- PMID:21862415
- PMID:21887501
- PMID:21903605
- PMID:21935916
- PMID:21989327
- PMID:22162924
- PMID:22198425
- PMID:22216781
- PMID:22282463
- PMID:22291464
- PMID:22514495
- PMID:22517020
- PMID:22555773
- PMID:22593439
- PMID:22619477
- PMID:22694309
- PMID:22739019
- PMID:22803519
- PMID:22829199
- PMID:22953094
- PMID:23010853
- Reaxys:11271529
- Ontology
- ChEBI ( EBI )
- is a type of
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- has_part
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- has_role
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Show first 5 Terms
Phenotype
Phenotype resulting from eribulin mesylate
Phenotype where environments contain eribulin mesylate
Phenotype modified by environments containing eribulin mesylate
Human Disease / Model Data
Citations