midodrine

Term ID

CHEBI:6933

Synonyms

• (+-)-2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide
• 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol
• 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide
• DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid
• midodrina
• midodrine
• midodrinum
• rac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide

Definition

An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

References

• Beilstein:2384653
• CAS:42794-76-3
• DrugBank:DB00211
• Drug_Central:1803
• HMDB:HMDB0014356
• KEGG:C07890
• KEGG:D08220
• LINCS:LSM-1815
• PMID:11096750
• PMID:15273244
• PMID:16676655
• PMID:17901021
• PMID:18410283
• PMID:18840368
• PMID:19522958
• PMID:20376815
• PMID:20844343
• PMID:21343575
• PMID:21801220
• PMID:22436941
• PMID:23051063
• Patent:GB1003659
• Patent:US3340298
• Reaxys:2384653
• Wikipedia:Midodrine

Ontology

ChEBI  ( EBI )

Resources

CTD