midodrine

Term ID

CHEBI:6933

Synonyms

• (+-)-2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide
• 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol
• 2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide
• DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid
• midodrina
• midodrine
• midodrinum
• rac-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide

Definition

An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective α-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

References

• cas:42794-76-3
• drugbank:DB00211
• drugcentral:1803
• hmdb:HMDB0014356
• kegg.compound:C07890
• kegg.drug:D08220
• lincs.smallmolecule:LSM-1815
• patent:GB1003659
• patent:US3340298
• pubmed:11096750
• pubmed:15273244
• pubmed:16676655
• pubmed:17901021
• pubmed:18410283
• pubmed:18840368
• pubmed:19522958
• pubmed:20376815
• pubmed:20844343
• pubmed:21343575
• pubmed:21801220
• pubmed:22436941
• pubmed:23051063
• reaxys:2384653
• wikipedia.en:Midodrine

Ontology

ChEBI  ( EBI )

Resources

CTD