alpha-methyl-L-tyrosine

Term ID

CHEBI:6912

Synonyms

• (-)-alpha-Methyl-L-tyrosine
• (S)-alpha-Methyltyrosine
• alpha-methyl-L-p-tyrosine
• alpha-methyl-L-tyrosine
• alpha-methyl-p-tyrosine
• alpha-methyl-para-tyrosine
• alpha-Methyltyrosine
• L-alpha-Methyltyrosine
• Methyltyrosine
• metirosina
• metirosine
• metirosinum
• Metyrosine

Definition

An L-tyrosine derivative that consists of L-tyrosine bearing an additional methyl substituent at position 2. An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma.

References

• cas:672-87-7
• drugbank:DB00765
• drugcentral:1792
• kegg.compound:C07921
• kegg.drug:D00762
• patent:US2011104765
• pubmed:28716505
• pubmed:29353821
• pubmed:29438107
• pubmed:29668781
• reaxys:2368400
• wikipedia.en:Metirosine

Ontology

ChEBI  ( EBI )