abiraterone acetate

Term ID

CHEBI:68639

Synonyms

(3beta)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate
17-(3-Pyridyl)-5,16-androstadien-3beta-acetate
17-(pyridin-3-yl)androsta-5,16-dien-3beta-yl acetate
Zytiga

Definition

A sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo into abiraterone. Used for treatment of metastatic castrate-resistant prostate cancer.

References

cas:154229-18-2
drugcentral:4176
kegg.drug:D09701
patent:US2008051380
patent:US2011201563
patent:WO2006021776
patent:WO2012083112
pubmed:15150570
pubmed:16809076
pubmed:18645193
pubmed:18957947
pubmed:19189435
pubmed:19470933
pubmed:19995520
pubmed:19995526
pubmed:20050017
pubmed:20159814
pubmed:20159823
pubmed:20159824
pubmed:20225998
pubmed:20465382
pubmed:20645691
pubmed:20805462
pubmed:21171672
pubmed:21243537
pubmed:21550166
pubmed:21632851
pubmed:21731216
pubmed:21743483
pubmed:21802835
pubmed:21804589
pubmed:21836546
pubmed:21896467
pubmed:21975570
pubmed:21985170
pubmed:22123334
pubmed:22130117
pubmed:22149426
pubmed:22184395
pubmed:22198164
pubmed:22291466
pubmed:22372727
pubmed:22430753
pubmed:22526411
pubmed:22752297
pubmed:22995653
pubmed:23020788
pubmed:23023354
reaxys:7314563

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from abiraterone acetate

Phenotype where environments contain abiraterone acetate

Phenotype modified by environments containing abiraterone acetate

Phenotype affecting abiraterone acetate

Human Disease Model