rilpivirine

Term ID

CHEBI:68606

Synonyms

4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
4-{[4-({4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
rilpivirine
TMC 278
TMC278

Definition

An aminopyrimidine that is pyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 4-cyanophenyl and 4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl groups respectively. Used for treatment of HIV.

References

cas:500287-72-9
drugbank:DB08864
hmdb:HMDB0061725
kegg.drug:D09720
patent:US2008280849
patent:WO2004016581
patent:WO2004069812
patent:WO2006035067
patent:WO2006035068
patent:WO2006035069
patent:WO2007082922
patent:WO2007113254
patent:WO2009007441
pdb-ccd:T27
pubmed:15771441
pubmed:15771449
pubmed:19048650
pubmed:19249947
pubmed:19328850
pubmed:19548857
pubmed:19678794
pubmed:20160045
pubmed:20438081
pubmed:21308448
pubmed:21373646
pubmed:21763920
pubmed:21763935
pubmed:21763936
pubmed:21860365
pubmed:21902621
pubmed:21997204
pubmed:22024527
pubmed:22067667
pubmed:22096405
pubmed:22209291
pubmed:22257626
pubmed:22293086
pubmed:22343174
pubmed:22356290
pubmed:22406117
pubmed:22430974
pubmed:22504027
pubmed:22519768
pubmed:22555080
pubmed:22567823
pubmed:22570576
pubmed:22664973
pubmed:22729755
pubmed:22842995
pubmed:22878339
pubmed:22921088
pubmed:22951490
pubmed:22955279
pubmed:25017682
reaxys:9952270
wikipedia.en:Rilpivirine

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from rilpivirine

Phenotype where environments contain rilpivirine

Phenotype modified by environments containing rilpivirine

Phenotype affecting rilpivirine

Human Disease Model