telaprevir

Term ID

CHEBI:68595

Synonyms

(1S,3aR,6aS)-(2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta(c)pyrrole-1-carboxamide
(1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide
Incivek
VX 950
VX-950

Definition

An oligopeptide consisting of N-(pyrazin-2-ylcarbonyl)cyclohexylalanyl, 3-methylvalyl, octahydrocyclopenta[c]pyrrole-1-carboxy, and 3-amino-N-cyclopropyl-2-oxohexanamide residues joined in sequence. Used for treatment of chronic hepatitis C virus genotype 1 infection.

References

cas:402957-28-2
drugcentral:4173
hmdb:HMDB0015616
kegg.drug:D09012
patent:US2005197301
patent:US2006252698
patent:US2006276405
patent:US2006276407
patent:US2006281688
patent:US2007087973
patent:WO2005025517
patent:WO2006127289
patent:WO2011103932
pubmed:20945948
pubmed:21884670
pubmed:21940388
pubmed:22039291
pubmed:22095516
pubmed:22169996
pubmed:22180548
pubmed:22212567
pubmed:22222799
pubmed:22239508
pubmed:22345334
pubmed:22383557
pubmed:22404758
pubmed:22423262
pubmed:22439668
pubmed:22471376
pubmed:22506260
pubmed:22511937
pubmed:22515133
pubmed:22537438
pubmed:22642697
pubmed:22806681
pubmed:22889114
pubmed:22902721
pubmed:22954756
pubmed:23016967
pubmed:25017682
reaxys:10511882
wikipedia.en:Telaprevir

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from telaprevir

Phenotype where environments contain telaprevir

Phenotype modified by environments containing telaprevir

Phenotype affecting telaprevir

Human Disease Model