linaclotide

Term ID

CHEBI:68551

Synonyms

Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (disulfide bridge: 1-6; 2-10; 5-13)
L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine cyclic (1->6),(2->10),(5->13)-tris(disulfide)
Linzess

Definition

A fourteen-membered heterodetic cyclic peptide consisting of Cys, Cys, Glu, Tyr, Cys, Cys, Asn, Pro, Ala, Cys, Thr, Gly, Cys and Tyr residues joined in sequence and cyclised by three disulfide bonds: between Cys(1) and Cys(6), between Cys(2) and Cys(10), and between Cys(5) and Cys(13). Used for treatment of irritable bowel syndrome accompanied by constipation.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: heterodetic cyclic peptide

heterodetic cyclic peptide Show first 5 Terms
has_role: guanylate cyclase 2C agonist

guanylate cyclase 2C agonist Show first 5 Terms

Phenotype

Phenotype resulting from linaclotide

Phenotype where environments contain linaclotide

Phenotype modified by environments containing linaclotide

Human Disease / Model Data

Citations