everolimus

Term ID

CHEBI:68478

Synonyms

• (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,35R)-1,18-dihydroxy-12-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,
• (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3
• 40-O-(2-hydroxyethyl)-rapamycin
• 42-O-(2-hydroxyethyl)rapamycin
• Afinitor
• Afinitor Disperz
• Certican
• everolimus
• everolimusum
• RAD 001
• RAD001
• SDZ RAD
• SDZ-RAD
• Votubia
• Xience V
• Zortress

Definition

A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted into the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent.

References

• cas:159351-69-6
• chemspider:21106307
• drugbank:DB01590
• drugcentral:1118
• hmdb:HMDB0015529
• kegg.drug:D02714
• lincs.smallmolecule:LSM-43172
• patent:CN102138903
• patent:RU2008143550
• patent:WO2012066502
• pubmed:22363408
• pubmed:22404500
• pubmed:22461124
• pubmed:22683823
• pubmed:22967800
• pubmed:22969095
• pubmed:22983698
• pubmed:22986894
• pubmed:31478889
• pubmed:33640871
• pubmed:33986025
• pubmed:33998365
• pubmed:34018490
• pubmed:34225066
• pubmed:34242751
• pubmed:34253597
• pubmed:34299359
• pubmed:34467233
• pubmed:34491881
• pubmed:34527569
• wikipedia.en:Everolimus

Ontology

ChEBI  ( EBI )