ruxolitinib

Term ID

CHEBI:66919

Synonyms

• (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
• INCB018424
• ruxolitinib

Definition

A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis.

References

• cas:941678-49-5
• drugcentral:4190
• kegg.drug:D09959
• lincs.smallmolecule:LSM-1139
• patent:US2008312258
• patent:US2010190981
• pubmed:21602517
• pubmed:21919691
• pubmed:21926964
• pubmed:22034658
• pubmed:22227528
• pubmed:22279053
• pubmed:22281165
• pubmed:22375970
• pubmed:22375971
• pubmed:22399854
• pubmed:22422826
• pubmed:22474318
• pubmed:22544377
• pubmed:22718840
• pubmed:22830345
• reaxys:18703668
• wikipedia.en:Ruxolitinib

Ontology

ChEBI  ( EBI )