semicochliodinol A

Term ID

CHEBI:66461

Synonyms

2,5-dihydroxy-3-(1H-indol-3-yl)-6-[5-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]cyclohexa-2,5-diene-1,4-dione

Definition

A bisindole alkaloid that is quinone bearing hydroxy substituents at positions 2 and 5 and two indol-3-yl groups at positions 3 and 6, one of which is carrying a prenyl group at position 5. Isolated from the culture broth of Chrysosporium merdarium, it acts as an inhibitor of HIV-1 protease and EGF-R protein tyrosine kinase.

References

PMID:9207909

Ontology

ChEBI ( EBI )

Relationships

is a type of: bisindole alkaloid dihydroxy-1,4-benzoquinones enol

bisindole alkaloid dihydroxy-1,4-benzoquinones enol Show first 5 Terms
has_role: epidermal growth factor receptor antagonist HIV protease inhibitor metabolite

epidermal growth factor receptor antagonist HIV protease inhibitor metabolite Show first 5 Terms

Phenotype

Phenotype resulting from semicochliodinol A

Phenotype where environments contain semicochliodinol A

Phenotype modified by environments containing semicochliodinol A

Human Disease / Model Data

Citations