TMC-86B

Term ID

CHEBI:66243

Synonyms

6-hydroxy-N-[(2S)-3-hydroxy-1-({1-[2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopent-4-en-2-yl}amino)-1-oxopropan-2-yl]-6-methylheptanamide

Definition

An epoxide that is oxiran-2-ylmethanol which is acylated at position 2 by N-(6-hydroxy-6-methylheptanoyl)-L-seryl-4-methylidenenorvalinyl group. It is a proteasome inhibitor isolated from Streptomyces.

References

PMID:10695669
PMID:10724010
Reaxys:8518741

Ontology

ChEBI ( EBI )

Relationships

is a type of: epoxide ketone monocarboxylic acid amide primary alcohol

epoxide ketone monocarboxylic acid amide primary alcohol Show first 5 Terms
has_role: antimicrobial agent antineoplastic agent bacterial metabolite proteasome inhibitor

antimicrobial agent antineoplastic agent bacterial metabolite proteasome inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from TMC-86B

Phenotype where environments contain TMC-86B

Phenotype modified by environments containing TMC-86B

Human Disease / Model Data

Citations