TMC-86A

Term ID

CHEBI:66242

Synonyms

N-[(2S)-3-hydroxy-1-[[1-[2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]-3-methylbutanamide

Definition

An epoxide that is oxiran-2-ylmethanol which is acylated at position 2 by N-butanoyl-L-seryl-4-methylidenenorvalinyl group. It is a proteasome inhibitor isolated from Streptomyces.

References

PMID:10695669
PMID:10724010
Reaxys:8510499

Ontology

ChEBI ( EBI )

Relationships

is a type of: diol epoxide ketone monocarboxylic acid amide primary alcohol ... Show All 6 Terms

diol epoxide ketone monocarboxylic acid amide primary alcohol secondary alcohol Show first 5 Terms
has_role: antimicrobial agent antineoplastic agent bacterial metabolite proteasome inhibitor

antimicrobial agent antineoplastic agent bacterial metabolite proteasome inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from TMC-86A

Phenotype where environments contain TMC-86A

Phenotype modified by environments containing TMC-86A

Human Disease / Model Data

Citations