gelomulide M

Term ID

CHEBI:65956

Synonyms

(1beta,5beta,7beta,9beta,10alpha,12beta,14beta)-16-oxo-8,14:12,16-diepoxyabieta-2,13(15)-diene-1,7-diyl diacetate
1beta,7beta-diacetoxy-8beta,14beta-epoxy-ent-abieta-2(3),13(15)-diene-16,12-olide

Definition

An abietane diterpenoid that is ent-abieta-2(3),13(15)-diene-16,12-olide substituted by beta-acetoxy groups at positions 1 and 7 and a beta-epoxy group across positions 8 and 14. Isolated from the leaves of Gelonium aequoreum, it exhibits moderate cytotoxicity against lung (A549), breast (MDAMB-231 and MCF7), and liver (HepG2) cancer cell lines.

References

PMID:17714747
Reaxys:15836698

Ontology

ChEBI ( EBI )

Relationships

is a type of: abietane diterpenoid acetate ester epoxide gamma-lactone organic heteropentacyclic compound

abietane diterpenoid acetate ester epoxide gamma-lactone organic heteropentacyclic compound Show first 5 Terms
has_role: antineoplastic agent metabolite

antineoplastic agent metabolite Show first 5 Terms

Phenotype

Phenotype resulting from gelomulide M

Phenotype where environments contain gelomulide M

Phenotype modified by environments containing gelomulide M

Human Disease / Model Data

Citations