bevirimat

Term ID

CHEBI:65484

Synonyms

• (3beta)-3-[(3-carboxy-3-methylbutanoyl)oxy]lup-20(29)-en-28-oic acid
• 3-O-(3',3'-dimethylsuccinyl) betulinic acid
• bevirimat
• bevirimatum
• BVM
• PA-457

Definition

A pentacyclic triterpenoid obtained by the formal condensation of 2,2-dimethylsuccinic acid with the 3-hydroxy group of betulinic acid. It is isolated from the Chinese herb Syzygium claviflorum. The first in the class of HIV-1 maturation inhibitors to be studied in humans, bevirimat was identified as a potent HIV drug candidate and several clinical trials were conducted, but development into a new drug was plagued by numerous resistance-related problems.

References

• cas:174022-42-5
• pubmed:16930665
• pubmed:19024627
• pubmed:19105849
• pubmed:19195334
• pubmed:19279107
• pubmed:20154583
• pubmed:20406463
• pubmed:22151792
• pubmed:22888428
• pubmed:8176401
• reaxys:7504927
• wikipedia.en:Bevirimat

Ontology

ChEBI  ( EBI )