carfilzomib

Term ID

CHEBI:65347

Synonyms

• carfilzomib
• Kyprolis
• N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninamide

Definition

A synthetic tetrapeptide consisting of morpholin-4-acetyl, L-2-amino-4-phenylbutanoyl, L-leucyl and L-phenylalanyl residues joined in sequence with the C-terminus connected to the amino group of (2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-1-one via an amide linkage. Used for the treatment of patients with multiple myeloma

References

• cas:868540-17-4
• drugcentral:4483
• kegg.drug:D08880
• pubmed:19348473
• pubmed:20937826
• pubmed:21905015
• pubmed:22235146
• pubmed:22411899
• pubmed:22507794
• pubmed:22507799
• pubmed:22555973
• pubmed:22621161
• pubmed:22645181
• pubmed:22665938
• pubmed:22726549
• pubmed:22727391
• pubmed:22734651
• pubmed:22761464
• pubmed:22763387
• reaxys:12488950
• wikipedia.en:Carfilzomib

Ontology

ChEBI  ( EBI )