crizotinib

Term ID

CHEBI:64310

Synonyms

(R)-crizotinib
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
crizotinib
crizotinibum
PF 2341066
PF-2341066

Definition

A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)

References

cas:877399-52-5
drugcentral:4187
kegg.drug:D09731
lincs.smallmolecule:LSM-1027
pubmed:21308771
pubmed:22129595
pubmed:22129984
pubmed:22191798
pubmed:22215748
pubmed:22233293
pubmed:22235099
pubmed:22277784
pubmed:22282074
pubmed:22311682
pubmed:22316363
pubmed:22321987
pubmed:22323827
pubmed:22385925
pubmed:22397764
pubmed:22435662
pubmed:22443113
pubmed:24427836
pubmed:24444403
pubmed:24455567
pubmed:24486291
pubmed:24491302
pubmed:24556908
reaxys:12133926
wikipedia.en:Crizotinib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from crizotinib

Phenotype where environments contain crizotinib

Phenotype modified by environments containing crizotinib

Phenotype affecting crizotinib

Human Disease Model