leupeptin

Term ID

CHEBI:6426

Synonyms

Ac-L-Leu-L-Leu-L-Arg-H
Ac-Leu-Leu-Arg-H
Ac-Leu-Leu-argininal
Ac-LLR-H
acetyl-L-leucyl-L-leucyl-L-argininal
N-acetyl-L-leucyl-L-leucyl-L-argininal
N-acetyl-L-leucyl-N-[(2S)-5-carbamimidamido-1-oxopentan-2-yl]-L-leucinamide
N-acetyl-leucylleucylargininal

Definition

A tripeptide composed of N-acetylleucyl, leucyl and argininal residues joined in sequenceby peptide linkages. It is an inhibitor of the calpains, a family of calcium-activated proteases which promote cell death.

References

cas:55123-66-5
hmdb:HMDB0254042
kegg.compound:C01591
metacyc.compound:LEUPEPTIN
pmc:PMC6750451
pubmed:11950531
pubmed:14704627
pubmed:15106277
pubmed:15804428
pubmed:15963736
pubmed:16707850
pubmed:17379854
pubmed:18093577
pubmed:18443109
pubmed:19168046
pubmed:20828747
pubmed:20844259
pubmed:21246210
pubmed:21460622
pubmed:22169219
pubmed:22206578
pubmed:22291646
pubmed:24393046
pubmed:25870226
pubmed:26365578
pubmed:26399337
pubmed:27919045
pubmed:28456988
pubmed:32609431
pubmed:33016476
pubmed:33512650
pubmed:34579576
pubmed:7295735
pubmed:9531495
reaxys:2402463
reaxys:24140639
wikipedia.en:Leupeptin

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from leupeptin

Phenotype where environments contain leupeptin

Phenotype modified by environments containing leupeptin

Phenotype affecting leupeptin

Human Disease Model