Search Ontology:
ChEBI

spiramide

Term ID
CHEBI:64207
Synonyms
  • 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
  • AMI-193
  • espiramida
  • spiramide
  • spiramidum
Definition
An azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from spiramide
Phenotype where environments contain spiramide
Phenotype modified by environments containing spiramide
Human Disease Model
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