Search Ontology:
ChEBI
spiramide
- Term ID
- CHEBI:64207
- Synonyms
-
- 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
- AMI-193
- espiramida
- spiramide
- spiramidum
- Definition
- An azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.
- References
-
- cas:510-74-7
- lincs.smallmolecule:LSM-4124
- patent:US3238216
- pubmed:11124389
- pubmed:17965538
- pubmed:19875674
- pubmed:4474849
- pubmed:4776656
- reaxys:631679
- wikipedia.en:Spiramide
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
Phenotype
Phenotype resulting from spiramide
Phenotype where environments contain spiramide
Phenotype modified by environments containing spiramide
Phenotype affecting spiramide
Human Disease Model