clobenpropit

Term ID

CHEBI:64177

Synonyms

3-(1H-imidazol-4-yl)propyl N-(4-chlorobenzyl)carbamimidothioate
S-(3-(4(5)-Imidazolyl))propyl-N-(4-chlorobenzyl)isothiourea

Definition

An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H₃ antagonist/inverse agonist (pA₂ = 9.93). Also displays partial agonist activity at H₄ receptors; induces eosinophil shape change with an EC₅₀ of 3 nM.

References

cas:145231-45-4
kegg.compound:C17934
lincs.smallmolecule:LSM-3600
pubmed:19895842
pubmed:20014479
pubmed:20093321
pubmed:20197375
pubmed:20432621
pubmed:20511290
pubmed:21134907
pubmed:21272571
pubmed:21554104
pubmed:21793031
pubmed:22003888
pubmed:22005500
pubmed:22011436
pubmed:22115898
pubmed:22331799
reaxys:5822910
wikipedia.en:Clobenpropit

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from clobenpropit

Phenotype where environments contain clobenpropit

Phenotype modified by environments containing clobenpropit

Phenotype affecting clobenpropit

Human Disease Model