imetit

Term ID

CHEBI:64156

Synonyms

2-(1H-imidazol-4-yl)ethyl carbamimidothioate
S-(2-(4-Imidazolyl)ethyl)isothiourea

Definition

An imidothiocarbamic ester that consists of isothiourea in which the thiol hydrogen is substituted by a 2-(imidazol-4-yl)ethyl group. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.

References

CAS:102203-18-9
KEGG:C17931
Reaxys:880781
Wikipedia:Imetit

Ontology

ChEBI ( EBI )

Relationships

is a type of: imidazoles imidothiocarbamic ester

imidazoles imidothiocarbamic ester Show first 5 Terms
has_role: H3-receptor agonist H4-receptor agonist

H3-receptor agonist H4-receptor agonist Show first 5 Terms
inverse is_conjugate_acid_of: imetit(2+)

imetit(2+) Show first 5 Terms
is_conjugate_base_of: imetit(2+)

imetit(2+) Show first 5 Terms

Phenotype

Phenotype resulting from imetit

Phenotype where environments contain imetit

Phenotype modified by environments containing imetit

Human Disease / Model Data

Citations