8-bromo-3',5'-cyclic GMP

Term ID

CHEBI:64108

Synonyms

8-Br-cGMP
8-Br-Cyclic GMP
8-Bromo-cgmp
8-Bromocyclic GMP
8-Bromocyclic guanosine monophosphate
8-bromoguanosine 3',5'-(hydrogen phosphate)
8-Bromoguanosine 3',5'-cyclic monophosphate
8-Bromoguanosine 3',5'-monophosphate

Definition

A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP bearing an additional bromo substituent at position 8 on the guanine ring. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.

References

CAS:31356-94-2
KEGG:C13817
PMID:10703694
PMID:18509055
PMID:18841072
PMID:21918260
Reaxys:1233440
Wikipedia:8-Bromoguanosine_3',5'-cyclic_monophosphate

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: 3',5'-cyclic purine nucleotide organobromine compound

3',5'-cyclic purine nucleotide organobromine compound Show first 5 Terms
has_functional_parent: 3',5'-cyclic GMP

3',5'-cyclic GMP Show first 5 Terms
has_role: muscle relaxant protein kinase G agonist

muscle relaxant protein kinase G agonist Show first 5 Terms

Phenotype

Phenotype resulting from 8-bromo-3',5'-cyclic GMP

Phenotype where environments contain 8-bromo-3',5'-cyclic GMP

Phenotype modified by environments containing 8-bromo-3',5'-cyclic GMP

Human Disease Model