Search Ontology:
ChEBI
vanoxerine
- Term ID
- CHEBI:64089
- Synonyms
-
- 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine
- GBR 12909
- GBR12909
- vanoxerina
- vanoxerine
- vanoxerinum
- Definition
- An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
- References
-
- cas:67469-69-6
- lincs.smallmolecule:LSM-2703
- pubmed:21146374
- pubmed:21198550
- pubmed:21334368
- pubmed:21396352
- pubmed:21615815
- pubmed:21694584
- pubmed:21820012
- pubmed:22043293
- pubmed:22134476
- pubmed:22296263
- pubmed:22344407
- reaxys:587912
- wikipedia.en:Vanoxerine
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from vanoxerine
Phenotype where environments contain vanoxerine
Phenotype modified by environments containing vanoxerine
Phenotype affecting vanoxerine
Human Disease Model