Search Ontology:
ChEBI
RS 39604
- Term ID
- CHEBI:64083
- Synonyms
-
- RS-67506
- RS67506
- Definition
- An aromatic ether that is the 3,5-dimethoxybenzyl derivative of N-(2-{4-[3-(4-amino-5-chloro-2-hydroxyphenyl)-3-oxopropyl]piperidin-1-yl}ethyl)methanesulfonamide. A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.
- References
-
- lincs.smallmolecule:LSM-2461
- pubmed:11739263
- pubmed:12095647
- pubmed:15272208
- pubmed:21689105
- pubmed:7582507
- pubmed:8903510
- pubmed:9243330
- pubmed:9689461
- reaxys:8524141
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from RS 39604
Phenotype where environments contain RS 39604
Phenotype modified by environments containing RS 39604
Phenotype affecting RS 39604
Human Disease Model