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ChEBI
RS 39604 hydrochloride
- Term ID
- CHEBI:64081
- Synonyms
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- 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(1-(2-methylsulphonylamino)ethyl-4-piperidinyl)-1-propanone hydrochloride
- N-{2-[4-(3-{4-amino-5-chloro-2-[(3,5-dimethoxybenzyl)oxy]phenyl}-3-oxopropyl)piperidin-1-yl]ethyl}methanesulfonamide hydrochloride
- RS 67506
- RS-67506
- RS67506
- Definition
- A hydrochloride salt obtained by mixing equimolar amounts of RS 39604 with hydrochloric acid. A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and alpha1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.
- References
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- CAS:168986-61-6
- Reaxys:8889150
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
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- has_part
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- has_role
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Show first 5 Terms
Phenotype
Phenotype resulting from RS 39604 hydrochloride
Phenotype where environments contain RS 39604 hydrochloride
Phenotype modified by environments containing RS 39604 hydrochloride
Human Disease Model