Search Ontology:
ChEBI
RS 39604 hydrochloride
- Term ID
- CHEBI:64081
- Synonyms
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- 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(1-(2-methylsulphonylamino)ethyl-4-piperidinyl)-1-propanone hydrochloride
- N-{2-[4-(3-{4-amino-5-chloro-2-[(3,5-dimethoxybenzyl)oxy]phenyl}-3-oxopropyl)piperidin-1-yl]ethyl}methanesulfonamide hydrochloride
- RS 67506
- RS-67506
- RS67506
- Definition
- A hydrochloride salt obtained by mixing equimolar amounts of RS 39604 with hydrochloric acid. A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and alpha1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.
- References
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- CAS:168986-61-6
- Reaxys:8889150
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
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- has_part
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- has_role
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Show first 5 Terms
Phenotype
Phenotype resulting from RS 39604 hydrochloride
Phenotype where environments contain RS 39604 hydrochloride
Phenotype modified by environments containing RS 39604 hydrochloride
Phenotype affecting RS 39604 hydrochloride
Human Disease Model