(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol

Term ID

CHEBI:64080

Synonyms

(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol
A 77636
A-77636
A77636

Definition

An isochromene that is 3,4-dihydroisochromene-5,6-diol bearing additional aminomethyl and 1-adamantyl substituents at positions 1 and 3 respectively (the 1R,3S-diastereomer). Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo.

References

LINCS:LSM-20969
Patent:EP870757
Patent:US6057364
Reaxys:5855679

Ontology

ChEBI ( EBI )

Relationships

is a type of: adamantanes catechols isochromenes primary amino compound

adamantanes catechols isochromenes primary amino compound Show first 5 Terms
has_role: antiparkinson drug dopamine agonist

antiparkinson drug dopamine agonist Show first 5 Terms
inverse is_conjugate_acid_of: (1R,3S)-3-(adamantan-1-yl)-1-(ammoniomethyl)-3,4-dihydroisochromene-5,6-diol(1+)

(1R,3S)-3-(adamantan-1-yl)-1-(ammoniomethyl)-3,4-dihydroisochromene-5,6-diol(1+) Show first 5 Terms
is_conjugate_base_of: (1R,3S)-3-(adamantan-1-yl)-1-(ammoniomethyl)-3,4-dihydroisochromene-5,6-diol(1+)

(1R,3S)-3-(adamantan-1-yl)-1-(ammoniomethyl)-3,4-dihydroisochromene-5,6-diol(1+) Show first 5 Terms

Phenotype

Phenotype resulting from (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol

Phenotype where environments contain (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol

Phenotype modified by environments containing (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol

Human Disease Model