Search Ontology:
ChEBI
exendin-4
- Term ID
- CHEBI:64073
- Synonyms
-
- Ex4
- exenatida
- exenatide
- exenatidum
- Exendin 4
- exendin-4
- Heloderma suspectum gila monster exendin-4
- His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
- L-histidylglycyl-L-alpha-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L
- Definition
- A bioactive polypeptide of 39 amino acid residues isolated from the saliva of the Gila monster (Heloderma suspectum). High-affinity glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM); potently induces cAMP formation without stimulating amylase release in pancreatic acini; potentiates glucose-induced insulin secretion in isolated rat islets; protects against glutamate-induced neurotoxicity. A synthetic version is called exenatide.
- References
-
- cas:141758-74-9
- kegg.compound:C15894
- kegg.drug:D04121
- patent:EP1908778
- pubmed:12364473
- pubmed:1313797
- pubmed:14565957
- pubmed:16353670
- pubmed:17053883
- pubmed:20149450
- pubmed:20404826
- pubmed:22310470
- pubmed:22334721
- pubmed:22338110
- pubmed:22356440
- pubmed:22363635
- pubmed:22384126
- reaxys:9040649
- wikipedia.en:Exenatide
- Ontology
- ChEBI ( EBI )
Phenotype
Phenotype resulting from exendin-4
Phenotype where environments contain exendin-4
Phenotype modified by environments containing exendin-4
Phenotype affecting exendin-4
Human Disease Model