exendin-4

Term ID

CHEBI:64073

Synonyms

Ex4
exenatida
exenatide
exenatidum
Exendin 4
exendin-4
Heloderma suspectum gila monster exendin-4
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
L-histidylglycyl-L-alpha-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L

Definition

A bioactive polypeptide of 39 amino acid residues isolated from the saliva of the Gila monster (Heloderma suspectum). High-affinity glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM); potently induces cAMP formation without stimulating amylase release in pancreatic acini; potentiates glucose-induced insulin secretion in isolated rat islets; protects against glutamate-induced neurotoxicity. A synthetic version is called exenatide.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: polypeptide

polypeptide Show first 5 Terms
has_role: glucagon-like peptide-1 receptor agonist hypoglycemic agent incretin mimetic

glucagon-like peptide-1 receptor agonist hypoglycemic agent incretin mimetic Show first 5 Terms

Phenotype

Phenotype resulting from exendin-4

Phenotype where environments contain exendin-4

Phenotype modified by environments containing exendin-4

Human Disease Model