SB 224289

Term ID

CHEBI:64069

Synonyms

(1'-methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone
SB224289

Definition

A member of the class of benzamides obtained by formal condensation of the carboxy group of 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid with the secondary amino group of 1'-methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidine]. Selective 5-HT1B receptor antagonist (pKi = 8.2). Displays >60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: 1,2,4-oxadiazole azaspiro compound benzamides organic heterotetracyclic compound

1,2,4-oxadiazole azaspiro compound benzamides organic heterotetracyclic compound Show first 5 Terms
has_role: serotonergic antagonist

serotonergic antagonist Show first 5 Terms
inverse is_conjugate_acid_of: SB 224289(1+)

SB 224289(1+) Show first 5 Terms
is_conjugate_base_of: SB 224289(1+)

SB 224289(1+) Show first 5 Terms

Phenotype

Phenotype resulting from SB 224289

Phenotype where environments contain SB 224289

Phenotype modified by environments containing SB 224289

Human Disease Model