CGP 78608

Term ID

CHEBI:64061

Synonyms

[(1S)-1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl]phosphonic acid

Definition

A phosphonic acid in which the hydrogen attached to phosphorous is substituted by a 1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl group. Potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays >500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 muM respectively). Anticonvulsant in vivo following systemic administration.

References

PMID:15223384
PMID:17405869
PMID:19394327
Patent:US6117873
Reaxys:8227979

Ontology

ChEBI ( EBI )

Relationships

is a type of: organobromine compound phosphonic acids quinoxaline derivative secondary amino compound

organobromine compound phosphonic acids quinoxaline derivative secondary amino compound Show first 5 Terms
has_part: CGP 78608(1+)

CGP 78608(1+) Show first 5 Terms
has_role: anticonvulsant NMDA receptor antagonist

anticonvulsant NMDA receptor antagonist Show first 5 Terms

Phenotype

Phenotype resulting from CGP 78608

Phenotype where environments contain CGP 78608

Phenotype modified by environments containing CGP 78608

Human Disease Model