Search Ontology:
ChEBI
CGP 78608
- Term ID
- CHEBI:64061
- Synonyms
-
- [(1S)-1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl]phosphonic acid
- Definition
- A phosphonic acid in which the hydrogen attached to phosphorous is substituted by a 1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl group. Potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays >500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 muM respectively). Anticonvulsant in vivo following systemic administration.
- References
- (all 5)
- Ontology
- ChEBI ( EBI )
- has_role
- has_part
- is a type of
Phenotype
Phenotype resulting from CGP 78608
Phenotype where environments contain CGP 78608
Phenotype modified by environments containing CGP 78608
Phenotype affecting CGP 78608
Human Disease Model
No data available