CGP 78608

Term ID

CHEBI:64061

Synonyms

[(1S)-1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl]phosphonic acid

Definition

A phosphonic acid in which the hydrogen attached to phosphorous is substituted by a 1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl group. Potent and selective NMDA antagonist that acts through the glycine site (IC₅₀ = 5 nM). Displays >500-fold selectivity over kainate and AMPA receptors (IC₅₀ values are 2.7 and 3 μM respectively). Anticonvulsant in vivo following systemic administration.

References

patent:US6117873
pubmed:15223384
pubmed:17405869
pubmed:19394327
reaxys:8227979

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from CGP 78608

Phenotype where environments contain CGP 78608

Phenotype modified by environments containing CGP 78608

Phenotype affecting CGP 78608

Human Disease Model