nebivolol

Term ID

CHEBI:64022

Synonyms

• (1RS,1'RS)-1,1'-[(2RS,2'SR)-bis(6-fluorochroman-2-yl)]-2,2'-iminodiethanol
• (1RS,1'RS)-2,2'-iminobis{1-[(2RS,2'SR)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol}
• dl-nebivolol
• nebivolol
• nebivololum

Definition

A racemate consisting of equal amounts of (R,S,S,S)-nebivolol and (S,R,R,R)-nebivolol. A cardioselective beta blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure.

References

• cas:118457-14-0
• drugbank:DB04861
• kegg.drug:D05127
• patent:US4654362
• pubmed:17661735
• pubmed:18078016
• pubmed:18083889
• pubmed:18221115
• pubmed:18786089
• pubmed:19443516
• pubmed:19815121
• pubmed:20620250
• pubmed:23314750
• reaxys:4789059
• wikipedia.en:Nebivolol

Ontology

ChEBI  ( EBI )