leflunomide

Term ID

CHEBI:6402

Synonyms

5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide
alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide
Arava
leflunomida
Leflunomide
leflunomidum

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

References

cas:75706-12-6
drugbank:DB01097
drugcentral:1552
hmdb:HMDB0015229
kegg.compound:C07905
kegg.drug:D00749
lincs.smallmolecule:LSM-3771
patent:DE2854439
patent:US4284786
pubmed:10515382
pubmed:10702725
pubmed:10890256
pubmed:11043056
pubmed:11053058
pubmed:11067959
pubmed:11271257
pubmed:11333342
pubmed:11340750
pubmed:11391470
pubmed:11475244
pubmed:11522581
pubmed:11707749
pubmed:11718154
pubmed:11876141
pubmed:11884931
pubmed:11994686
pubmed:12017890
pubmed:12074690
pubmed:12833393
pubmed:14622739
pubmed:15030575
pubmed:15127968
pubmed:15127974
pubmed:15188371
pubmed:15214907
pubmed:15385935
pubmed:15489872
pubmed:15537652
pubmed:15652966
pubmed:15665760
pubmed:15789891
pubmed:15899055
pubmed:15934905
pubmed:16106593
pubmed:16142756
pubmed:16202258
pubmed:16284916
pubmed:16638062
pubmed:16638420
pubmed:16645972
pubmed:16688677
pubmed:16769661
pubmed:16778342
pubmed:17366662
pubmed:17604599
pubmed:17646975
pubmed:17854740
pubmed:18034546
pubmed:18173611
pubmed:18413415
pubmed:18496682
pubmed:18663553
pubmed:18688040
pubmed:19169882
pubmed:19190124
pubmed:19344337
pubmed:19581389
pubmed:19715969
pubmed:19751817
pubmed:19770782
pubmed:7496341
pubmed:7676489
pubmed:8610393
pubmed:9075844
pubmed:9123314
pubmed:9625011
pubmed:9777697
reaxys:4323174
wikipedia.en:Leflunomide

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

Phenotype

Phenotype resulting from leflunomide

Phenotype where environments contain leflunomide

Phenotype modified by environments containing leflunomide

Phenotype affecting leflunomide

Human Disease Model