Search Ontology:
ChEBI

7-chlorokynurenic acid

Term ID
CHEBI:63965
Synonyms
  • 7-chloro-4-hydroxy-2-carboxyquinoline
  • 7-chloro-4-hydroxyquinoline-2-carboxylic acid
  • 7-CKA
  • 7-Cl-KYNA
Definition
A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from 7-chlorokynurenic acid
Phenotype where environments contain 7-chlorokynurenic acid
Phenotype modified by environments containing 7-chlorokynurenic acid
Human Disease Model
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