necrosulfonamide

Term ID

CHEBI:63770

Synonyms

(2E)-N-{4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl}-3-(5-nitrothiophen-2-yl)prop-2-enamide
(E)-N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide

Definition

A sulfonamide that is a 3-methoxypyrazin-2-yl derivative of (E)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide. Necrosulfonamide specifically blocks necrosis downstream of the activation of RIP3 (the receptor-interacting serine-threonine kinase 3), a key signalling molecule in the programmed necrosis (necroptosis) pathway.

References

pubmed:22265413
pubmed:29614353
pubmed:30391637
pubmed:31998134
pubmed:32196619
pubmed:32936609
pubmed:33612303
pubmed:34119493
pubmed:35263988
pubmed:35588872
pubmed:35721316
pubmed:36202154
pubmed:36347275
pubmed:36381100
pubmed:37258791

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from necrosulfonamide

Phenotype where environments contain necrosulfonamide

Phenotype modified by environments containing necrosulfonamide

Phenotype affecting necrosulfonamide

Human Disease Model