pemetrexed disodium heptahydrate

Term ID

CHEBI:63723

Synonyms

Alimta
disodium N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate--water (1/7)
Pemetrexed sodium hydrate

Definition

An organic sodium salt that is the heptahydrate form of pemetrexed disodium. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).

References

DrugBank:DB00642
KEGG:D06503
Reaxys:15489532

Ontology

ChEBI ( EBI )

Relationships

is a type of: hydrate organic sodium salt

hydrate organic sodium salt Show first 5 Terms
has_part: pemetrexed disodium

pemetrexed disodium Show first 5 Terms
has_role: antimetabolite antineoplastic agent EC 1.5.1.3 (dihydrofolate reductase) inhibitor EC 2.1.1.45 (thymidylate synthase) inhibitor EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor

antimetabolite antineoplastic agent EC 1.5.1.3 (dihydrofolate reductase) inhibitor EC 2.1.1.45 (thymidylate synthase) inhibitor EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from pemetrexed disodium heptahydrate

Phenotype where environments contain pemetrexed disodium heptahydrate

Phenotype modified by environments containing pemetrexed disodium heptahydrate

Human Disease / Model Data

Citations