pemetrexed disodium

Term ID

CHEBI:63722

Synonyms

• disodium (2S)-2-({4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}amino)pentanedioate
• disodium N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

Definition

An organic sodium salt that is the disodium salt of N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).

References

• CAS:150399-23-8
• DrugBank:DB00642
• KEGG:D03828
• PMID:19137122
• PMID:20209614
• Patent:CN101411710
• Patent:CN101560206
• Patent:EP2301909
• Patent:EP2334685
• Patent:US2009181990
• Patent:US2011124861
• Patent:US2011196154
• Patent:WO2010028105
• Patent:WO2011019986
• Patent:WO2011064256
• Reaxys:8964395

Ontology

ChEBI  ( EBI )