tenofovir disoproxil

Term ID

CHEBI:63717

Synonyms

9-((R)-2-((bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine
bis(POC)PMPA
bis({[(propan-2-yloxy)carbonyl]oxy}methyl) ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonate
PMPA prodrug
tenofovir bis(isopropyloxycarbonyloxymethyl) ester

Definition

An organic phosphonate that is the disoproxil ester of tenofovir. A prodrug for tenofovir, an HIV-1 reverse transcriptase inhibitor, tenofovir disoproxil is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.

References

CAS:201341-05-1
DrugBank:DB00300
Drug_Central:2593
Patent:WO5922695
Patent:WO9804569
Reaxys:9018187

Ontology

ChEBI ( EBI )

Relationships

is a type of: organic phosphonate

organic phosphonate Show first 5 Terms
has_functional_parent: tenofovir (anhydrous)

tenofovir (anhydrous) Show first 5 Terms
has_role: antiviral drug HIV-1 reverse transcriptase inhibitor prodrug

antiviral drug HIV-1 reverse transcriptase inhibitor prodrug Show first 5 Terms
inverse has_part: tenofovir disoproxil fumarate

tenofovir disoproxil fumarate Show first 5 Terms

Phenotype

Phenotype resulting from tenofovir disoproxil

Phenotype where environments contain tenofovir disoproxil

Phenotype modified by environments containing tenofovir disoproxil

Human Disease / Model Data

Citations