vemurafenib

Term ID

CHEBI:63637

Synonyms

N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide
PLX 4032
PLX-4032
PLX4032
RG 7204
RG-7204
RG7204
Ro 51-85426
RO 5185426
RO-51-85426
RO-5185426
RO5185426
vemurafenib
vemurafenibum
Zelboraf

Definition

A pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine which is substituted at position 5 by a p-chlorophenyl group and at positions 3 by a 3-amino-2,6-difluorobenzoyl group, the amino group of which has undergone formal condensation with propane-1-sulfonic acid to give the corresponding sulfonamide. An inhibitor of BRAF and other kinases.

References

cas:918504-65-1
drugbank:DB08881
drugcentral:4185
kegg.drug:D09996
lincs.smallmolecule:LSM-1068
patent:WO2010114928
pdb-ccd:032
pubmed:21609436
pubmed:21639808
pubmed:22028422
pubmed:22037033
pubmed:22083257
pubmed:22180495
pubmed:23866896
pubmed:29999925
pubmed:33595357
pubmed:34433660
pubmed:35740068
pubmed:36396045
pubmed:36431901
pubmed:36598578
pubmed:36612138
pubmed:36713531
pubmed:36765875
pubmed:36855200
pubmed:36906728
pubmed:36977328
pubmed:37021539
pubmed:37106808
pubmed:37215493
pubmed:37216396
pubmed:37309702
pubmed:37325052
pubmed:37419396
pubmed:37436162
pubmed:37446932
pubmed:37456058
pubmed:37459870
pubmed:37459873
reaxys:12833468
wikipedia.en:Vemurafenib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from vemurafenib

Phenotype where environments contain vemurafenib

Phenotype modified by environments containing vemurafenib

Phenotype affecting vemurafenib

Human Disease Model